Journal of Diabetes Research and Management

Metabolism and Obesity in Diabetes

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The top global contributors to shorter health and life expectancies are obesity and diabetes mellitus. Diabetes and insulin intolerance also have a close association with body mass index. Nonesterified fatty acids, glycerol, hormones, cytokines, proinflammatory markers, and other compounds implicated in developing insulin resistance are detected in higher concentrations in obese people. The development and increasing prevalence of type 1 and type 2 diabetes is primarily attributed to increased weight and body mass. The elucidation of novel processes underlying these metabolic disorders pave the way for developing fresh potential therapeutic approaches.